Receptivity-based uterine fibroid surgery: an updated systematic review of the evidence

Background: Analyzing expression patterns of receptivity genes is a minimally invasive diagnostic method to identify the underlying cause subfertility in women with uterine fibroid history implantation failure or recurrent pregnancy loss. This updated systematic review was designed determine molecular and genetic changes endometrium how myomctomy affect outcome spontaneous assisted conception treatment. We also discussed extent which we should consider effects fibroids on endometrial when deciding whether not perform myomectomy. Methods: A total 184 articles reached as result PubMed research meeting selection criteria, were evaluated. Of these, 28 full text leiomyoma endometrium, receptivity, implantation, myomectomy genes, surgery peristalsis, immune cell Results: The subfertile appears have disease specific pattern according type fibroid. response may vary depending close far from it. Leiomyomas that contribute must be near contact case for Types 0, 1 2 leiomyomas. proximity cavity makes effect more pronounced. While Type 3 causes similar submucosal fibroids, subfertility-producing 4 been clearly clarified. However, fact mean it has no endometrium. mechanical stress created by connected converted into biological signal disrupt receptivity. Data restores impaired are mostly based clinical observations, studies evaluating before after very few. Conclusions: Analysis assist clinician If determined other than their effects, indications expand narrow.